Shelf life of chemicals pdf

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Shelf life of chemicals pdf

Labs generally do a good job of managing their chemical inventories. However, oversight of laboratory chemicals tends to be less controlled than that of waste chemicals.

Materials at this end of the process are just as volatile and can, in fact, be more of a hazard because they are no longer in their original containers, may be mixed with other, potentially reactive agents, or simply may have decomposed due to age and become less stable.

Virtually all labs have established procedures, but they may be outdated or the staff may be uninformed or poorly trained.

We occasionally encounter unexpected mixtures that, at best, present storage and disposal challenges and, at worst, are dangerous for lab personnel as well as the environment. Such encounters point to the fact that all labs must periodically review their policies, develop procedures, and conduct training for managing hazardous waste inventories. Working for a company that removes hazardous waste from labs enables me and my staff to witness the full spectrum of chemical management practices.

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Corporate and industrial labs are easier to control, since they tend to conduct repetitive processes that use defined sets of chemicals. Research and, particularly, academic labs are less stringent than other labs due to the number of researchers, the broader range of chemicals used, and the temporary nature of student researchers.

Occasionally, we see labs that have grown quickly and outpaced their chemical management procedures. The chemical life cycle spans three stages. The first is chemical inventory, which relates to the procurement, storage, and management of chemicals before they are used; the second is the use of chemicals in research or processes; and the third is post-use, which is when the chemicals or new compounds move to waste storage and removal.

Effective chemical life cycle management is centered on expiration dates, which must be noted when chemicals arrive at the lab and tracked until they are removed. Chemical inventory management should be relatively easy since materials arrive in approved, labeled containers supported by paperwork.

Nevertheless, a few factors challenge effective management. One factor is that, in order to save money, many labs purchase chemicals in bulk.

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It is better to buy smaller quantities and turn inventory over more frequently, because old chemicals are potentially dangerous. An example of a chemical with a short shelf life is peroxide formers, such as diethyl ether, which can form explosive peroxides and subsequently become unstable. These and other chemicals require close tracking to avoid exceeding their expiration dates. Saving a percentage of the cost reflects a false economy if the materials remain unused and the lab has to pay a company thousands of dollars to remotely open the container and then stabilize and dispose of the chemical.

Generally, the best practice is to have a centralized purchasing and inventory process that purchases appropriate quantities for the organization, manages the inventory, and dispenses chemicals as necessary. Chemical inventory storage is also an issue. Chemicals are occasionally stored alphabetically. Commingling incompatible but alphabetically sequential chemicals, such as acetone and benzoyl peroxide, can lead to explosive chemical reactions.

Compatible chemicals should be stored together within secondary containers or trays to sequester spills. When stored over two years, hydrogen fluoride reacts with the iron in the bottle and begins to form hydrogen gas. The hydrogen gas builds up over time to the point where the bottle can rupture.

For the next two stages, once chemicals are removed from their original containers for use or waste storage, all labs should adhere to Title 29 of the Code of Federal Regulations, Section This extends to smaller dispensing containers, such as isopropyl alcohol spray bottles, cleaning chemicals, and other materials that may or may not be part of the research or production process.

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A chemical hygiene officer should be designated, as required under the Code of Federal Regulations, Title 29, Section He or she should be actively involved in the development of procedures, proper labeling of containers, communications, and training of lab personnel related to the proper management of chemicals. The chemical hygiene officer is ultimately responsible for ensuring that all regulations are met and that a safe management protocol is followed.

The protocol must cover the full life cycle.

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Waste chemicals pose additional challenges in that they may no longer be in their original containers; their use in processes or research may cause the formation of new compounds; and they are often mixed with the same chemical from a different batch based on expiration date of other compatible chemicals.

Yet, some chemicals that would seem to be compatible are not. It is necessary to do a full evaluation of the byproduct of any mixture.Kappler is not aware of an accepted industry standard for determining shelf life of chemical barrier fabrics. Aged fabric has also been tested for physical properties and still meets manufacturing specifications.

Chemical protection suits contain components made from various polymer or rubber materials for which there is no specific shelf life data currently available. The garments may therefore be used as long as they are deemed safe after a visual inspection, and, in the case of vapor protective Level A garments, after passing the ASTM F pressure test. It is the responsibility of the wearer to ensure that all components, including fabric, valves, visors, gloves, zippers, seams, and suit-to component interfaces are in good working condition, and provide adequate protection for the operation and chemicals to be encountered.

Technical Services Department Kappler, Inc. Download PDF Version. Y'all Call The best protective apparel advice comes with a southern accent. Have suit questions? Need a chemical tested? Want a sample suit to evaluate? Kappler garments are made with American pride in Alabama where the accent is always on quality.Shelf life is the length of time that a commodity may be stored without becoming unfit for use, consumption, or sale.

It applies to cosmeticsfoods and beveragesmedical devicesmedicinesexplosivespharmaceutical drugschemicalstyresbatteries and many other perishable items. In some regions, an advisory best beforemandatory use by or freshness date is required on packaged perishable foods. The concept of expiration date is related but legally distinct in some jurisdictions. Shelf life is the recommended maximum time for which products or fresh harvested produce can be stored, during which the defined quality of a specified proportion of the goods remains acceptable under expected or specified conditions of distribution, storage and display.

If the cans look okay, they are safe to use. Discard cans that are dented, rusted, or swollen. High-acid canned foods tomatoes, fruits will keep their best quality for 12 to 18 months; low-acid canned foods meats, vegetables for 2 to 5 years.

Most food is still edible after the expiration date. In most food stores, waste is minimized by using stock rotationwhich involves moving products with the earliest sell by date from the warehouse to the sales area, and then to the front of the shelf, so that most shoppers will pick them up first and thus they are likely to be sold before the end of their shelf life.

shelf life of chemicals pdf

Some stores can be fined for selling out of date products; most if not all would have to mark such products down as wastedresulting in a financial loss. Shelf life depends on the degradation mechanism of the specific product. Most can be influenced by several factors: exposure to lightheatmoisture, transmission of gasesmechanical stressesand contamination by things such as micro-organisms. Product quality is often mathematically modelled around a parameter concentration of a chemical compound, a microbiological index, or moisture content.

For some foods, health issues are important in determining shelf life. Bacterial contaminants are ubiquitous, and foods left unused too long will often be contaminated by substantial amounts of bacterial colonies and become dangerous to eat, leading to food poisoning.

However, shelf life alone is not an accurate indicator of how long the food can safely be stored. For example, pasteurized milk can remain fresh for five days after its sell-by date if it is refrigerated properly. However, improper storage of milk may result in bacterial contamination or spoilage before the expiration date.

The expiration date of pharmaceuticals specifies the date the manufacturer guarantees the full potency and safety of a drug. Most medications continue to be effective and safe for a time after the expiration date. A rare exception is a case of renal tubular acidosis purportedly caused by expired tetracycline. Food and Drug Administration covered over drugs, prescription and over-the-counter. Joel Davis, a former FDA expiration-date compliance chief, said that with a handful of exceptions - notably nitroglycerin, insulin and some liquid antibiotics - most expired drugs are probably effective.

Shelf life is not significantly studied during drug development [ dubious — discuss ]and drug manufacturers have economic and liability incentives to specify shorter shelf lives so that consumers are encouraged to discard and repurchase products. One criticism is that the U. The SLEP and FDA signed a memorandum that scientific data could not be shared with the public, public health departments, other government agencies, and drug manufacturers.

Preservatives and antioxidants may be incorporated into some food and drug products to extend their shelf life. Shelf-life is not to be confused with service-life defined as, A general term used to quantify the average or standard life expectancy of an item or equipment while in use.

When a shelf-life item is unpacked and introduced to mission requirements, installed into intended application, or merely left in storage, placed in pre-expended bins, or held as bench stockshelf-life management stops and service life begins. Shelf life is often specified in conjunction with a specific product, package, and distribution system.

Nearly all chemical reactions can occur at normal temperatures although different reactions proceed at different rates. However most reactions are accelerated by high temperatures, and the degradation of foods and pharmaceuticals is no exception. The same applies to the breakdown of many chemical explosives into more unstable compounds.

Nitroglycerine is notorious. Old explosives are thus more dangerous i.To browse Academia. Skip to main content. Log In Sign Up. IJAR Indexing. IJAR Journal. ISSN: Int. Manuscript Info Abstract ……………………. Holding solution Received: 29 September should contain chemical preservatives to prolong the vase-life of cut Final Accepted: 30 October flowers.

These holding solutions must contain germicide to control Published: November harmful bacteria and prevent plugging of the conducting tissues. For many years, floral preservatives have been acidified and have usually Key words:- included biocides to inhibit bacterial proliferation. The sugars provide a Cosmos sulphreus, Chemical respiratory substrate, while the germicides control harmful bacteria and Preservative, Shelf life, Sucrose, Citric prevent plugging of the conducting tissues.

For flower opening, large acid. Present study was carried out for Cosmos sulphreus Cav. Cut flowers.

Managing Chemical Life Cycles

Various chemical preservatives were used to prolong shelf life of cut flower of Cosmos sulphreus. All rights reserved. Introduction:- India has an ancient heritage when it comes to floriculture. India is the second largest producer of flowers after China Mathur and Pachpande, Floriculture products consist of cut flowers, loose flowers, potted plants, plant rentals, seeds, bulbs, tubers, rooted cuttings and dried flowers or leaves.

Floriculture products are classified in two categories: Cut flowers and foliage; Plants and young plant material including bulbs, tubers, tuberous roots, rhizomes, corms, flowering plants, rooted and un-rooted cuttings.

Among all products cut flowers are in considerable demand in both domestic and export markets. Besides floral arrangements, Cosmos is widely used in bouquets and in dry flower crafts. The cut flowers have a long vase-life, which fetches premium market prices. Keeping quality is an important parameter for evaluation of cut flower quality, for both domestic and export markets.

Prolonging vase life of cut flower is one of the most important aspect fields of floristry Umebeseet al. Among all flower organs, petals primarily determine the commercial longevity of the flowers and as a result much attention has been given to the physiological and biochemical processes that occur during petal senescence.

Petal senescence is visibly shown by wilting or withering which vary depending on the species. Wilting of petals is due to loss of turgidity while withering is a colour change and slow dehydration. In most of the species flowers shows visible symptoms of senescence, i. In some species like Carnation, abscission takes place much later than visible senescence while in Corresponding Author:-Ruby Patel.

Prolonged vase life is one of the most important factors for quality of cut flowers.But to maintain the original high degree of purity certain procedures should be observed with regard to storage and handling. For example, impurities can form due to thermal or photolytic decomposition as well as through formation of free radicals.

Shelf life

Adverse reactions with atmospheric oxygen can produce dangerous peroxides and dryness can be degraded by contamination with atmospheric moisture.

Effects of this kind differ from product to product and can be more noticeable over a period of time, especially when combining the sensitivity of modern analytical instrumentation with the very high purity of ROMIL laboratory products. At ROMIL we minimise these problems by manufacturing and filling under an inert atmosphere of dry nitrogen.

This means that when we supply a product with, for example, a 2 years shelf life it means exactly that. The shelf life has not been degraded, say, for 18 months, whilst sitting in our warehouse, leaving only 6 months for the customer to use it. So to obtain the best performance from ROMIL products they should be used within the defined period of time and stored in such a way that minimises impurity build-up.

To prevent contamination it is good practice to dispense from the container rather than withdraw product with pipettes or other glassware. Do not return unused material and always replace the original closure immediately after use. Partially-used bottles of solvents should be purged with dry nitrogen or other inert gas before replacing the cap in order to maintain the optimum UV transparency.

Pack sizes should be chosen appropriate to the method. Whilst large containers may be suitable for HPLC gradients or for extraction prior to GC, smaller bottles are more suited to purely spectroscopic applications which consume much less solvent.

Can You Take Expired Drugs?

Smaller pack sizes are also worth considering for those products which may deteriorate on atmospheric exposure. Certified reference solutions and volumetric reagents should be gently shaken before use to maintain homogeneity which can be degraded due to water condensation on the inner surface of the container. This will also address striaition effects which may develop on long term storage. We recommend that products are kept in a cool and dry place, preferably in the dark and certainly out of direct sunlight.

The solvent or acid cupboard below the laboratory bench is ideal and indeed modern safety regulations require that such chemicals are stored in appropriate cupboards whilst not in use. Long-term exposure to excessively warm temperatures should be avoided.

Shelf Life of Chemicals

These quality systems are designed to ensure that data from laboratory studies is both reliable and reproducible. All ROMIL bottles carry a batch number for unique identification purposes and to help customers comply with GLP requirements our labels also bear the following additional information on stability and storage:.

Note that the shorter shelf life after opening must run within the unopened period otherwise it should be reduced accordingly. For example, if the recommended expiry after opening is 3 months then if the bottle is opened, say, 2 months from the expiry date, then the expiry after opening is reduced to 2 months.

It is not to be assumed that products suddenly become unuseable after the expiry date. Rather, the user should make a judgement based on knowledge and experience as to whether the product can continue to be used for the technique in mind. One way to do this would be to re-test the key purity parameters as defined on the label or specified in a written method.

Record the results in the laboratory journal and annotate the product label. But even so, a high purity solvent or acid should still be suitable for less demanding applications beyond its recommended shelf life.

shelf life of chemicals pdf

We are proud that ROMIL, during the mid s, were the first to introduce such an enhancement to the labelling of laboratory chemicals. Whilst this has now become an industry standard requirement, the clarity of the ROMIL approach and system of shelf life control continues to far exceed all others. All rights reserved.Federal government websites often end in.

The site is secure. Shelf life items are products that are effective, useful or suitable for consumption for a limited time period. They are expected to deteriorate or become unstable to the degree that a storage period must be assigned to assure that the material will perform satisfactorily in service. In short, the item spoils or will not perform its intended function for the customer after long-term, or even short-term, storage.

All of these shelf life items are recognized for their sensitivity to light, temperature, moisture or handling. Packaging deterioration and improper storage or preservation can also adversely affect shelf life. In order to assure maximum customer use of shelf life items, each of these items must be identified, including newly procured items having limited serviceability. Expired shelf life items no longer support the customer's mission, and incur additional costs for disposal.

DoD customers maintain stocks of shelf life products to support their mission. GSA is sensitive to their needs concerning these items. Type I items expire at expiration date, when material is unfit for use.

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Type II items can be extended by either visual inspection or laboratory test, as required by the applicable management activity storage standards. The Department of Defense maintains a website with multiple reference documents regarding shelf life topics. If you select on "Policy" in the left column at this site, you will see documents including:. FED-STD provides guidance on how the depots determine shelf life extensions for products currently stored in their facility.

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In accordance with DoD The role of each DoD Inventory Control Point ICP is to determine storage standards for deteriorative items that they manage, and to arrange for laboratory shelf life extension tests when their Installation Supply Activities request such tests.

Storage standards including length of shelf life and whether an item requires only a visual inspection or a full laboratory test in order to extend shelf life are recorded in the on-line Material Quality Control Storage Standards MQCSS.

Each ICP has update rights to this system. The type of test required on each item visual inspection or laboratory testing is determined by the managing ICP. If an installation finds that shelf life extension information is not available in the QSL for one of its items, staff can contact their service ICP for further instructions on possible extensions. Laboratory test requests are only allowed when there has not already been a shelf life test for that NSN, Manufacturer, Lot and Batch, and when the quantities of material in question warrant the expense of laboratory testing.

When these tests are accomplished, test results and extension data are entered into the QSL. For more information or questions, contact Jawad Abdeljawad at jawad. GSA Shelf Life Management Program Shelf life items are products that are effective, useful or suitable for consumption for a limited time period. Guidance and Direction for Shelf Life Material The Department of Defense maintains a website with multiple reference documents regarding shelf life topics.

If you select on "Policy" in the left column at this site, you will see documents including: DoD DoD Installation Responsibility If an installation finds that shelf life extension information is not available in the QSL for one of its items, staff can contact their service ICP for further instructions on possible extensions. Last Reviewed: The following general suggestions for safe storage of chemicals in the laboratory should be implemented.

In addition to general safe storage practices, segregated storage of incompatible materials is a must. As a minimum, laboratories should separate chemicals according to similar hazards, such as flammability, corrosivity, sensitivity to water or air, and toxicity. The following major categories of chemicals, each of which will be discussed in greater detail, are strongly recommended:. However, problems may arise with a general segregation of chemicals.

Below, you will find a few of these potential problems. Peroxides are very unstable and some chemicals that can form them are commonly used in laboratories.

This makes peroxide-forming materials some of the most hazardous substances found in a lab. Peroxide-forming materials are chemicals that react with air, moisture, or impurities to form peroxides. The tendency to form peroxides by most of these materials is greatly increased by evaporation or distillation. Organic peroxides are extremely sensitive to shock, sparks, heat, friction, impact, and light. Many peroxides formed from materials used in laboratories are more shock sensitive than TNT.

Just the friction from unscrewing the cap of a container of an ether that has peroxides in it can provide enough energy to cause a severe explosion. Recommendations for Storage of Laboratory Chemicals The following general suggestions for safe storage of chemicals in the laboratory should be implemented.

Many authorities recommend that the NFPA guidelines for maximum quantities and sizes of containers should be reduced to one-half or even one-third of the recommended values. Bulk quantities of chemicals i. Transfer of flammable liquid from 5 gallon or larger metal containers may not be done in the laboratory. Chemicals must be stored at an appropriate temperature and humidity level.

This can be especially problematic in hot, humid climates. As a rule, chemicals should not be stored near heat sources, such as steam pipes or laboratory ovens. Chemicals should never be stored in direct sunlight.

shelf life of chemicals pdf

Chemicals should be dated when received and when opened.


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